This course explores the physiological mechanisms of disease and resistance, social definitions of disease and gender-related factors in research, diagnosis, treatment, and adaptation to disease. Diseases are usually studied in generic terms without regard to gender; however, it is apparent that substantial differences exist in cis-male, cis-female and LGBTQI individuals' susceptibility, manifestation, and responses to many diseases. Just as significantly, society's responses to disease are clearly influenced by gender issues. These issues are explored through the perspective of both natural and social sciences.